已知α-干扰素(α-IFN)对低度恶性(低恶)非霍奇金淋巴瘤(NHL)是一种有效的抗肿瘤药物。其有效率30%。为了评估低恶和某些中恶组织学变型的NHL 患者对细胞毒化疗加α-IFN 的疗效,作者进行了随机的前瞻性研究。方法可评估的127例患者随机分配采用 CO-PA 方案,该方案为环磷酰胺(C)600mg/m~2静注第1天,长春新硷(O)1.2mg/m~2静注第1天,阿霉素 It is known that α-interferon (α-IFN) is a potent anti-tumor drug for low-grade (low-evil) non-Hodgkin’s lymphoma (NHL). Its efficiency is 30%. In order to evaluate the efficacy of cytotoxic chemotherapy plus α-IFN in patients with low-grade and moderately malignant histological variants of NHL, the authors performed a randomized prospective study. METHODS: 127 patients who could be evaluated were randomly assigned to use the CO-PA regimen. The regimen was cyclophosphamide (C) 600 mg/m 2 intravenous injection on day 1 and Changchun Xinmao (O) 1.2 mg/m 2 intravenous injection. 1 day, doxorubicin