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临床实践中慢性粒细胞性白血病(简称慢粒)作脾脏放射后偶可得长期缓解,有的尚可出现全血细胞减少与骨髓再生障碍,原因不明髓性化生患者中也偶有这种现象。过去对这种现象的解释是:(1)脾经放射后能释放一种抑制骨髓功能的体液因素;(2)脾在放射时流经脾脏的造血成分直接受到损伤。这些学说虽有可能,但尚不能完全解释上述现象。
Clinical practice of chronic myelogenous leukemia (referred to as CML) for spleen after radiotherapy can even have long-term relief, and some may still be pancytopenia and bone marrow regeneration disorders, the reason is also rare in patients with myeloid metaplasia . The past explanation of this phenomenon is: (1) the spleen can release a humoral factor that inhibits bone marrow function after radiation; and (2) the spleen’s hematopoietic components that pass through the spleen during radiation are directly damaged. Although these theories are possible, we can not fully explain the above phenomenon.