1975年,日本开始研究5-氟脲嘧啶(5-Fu)干糖浆的临床疗效,并于1976、1978年用生物测定法初步测定了病人及犬口服干糖浆后的血药浓度,但未说明药代动力学参数。本文采用氟离子选择电极法并通过薄层层析测定了家兔口服干糖浆后的血药浓度,并计算药代动力学参数如下:K_e=0.3108小时~(-1),K_a=0.8332小时~(-1);t(1(?)2)(吸收)=0.83小时,t_(1(?)β)= In 1975, Japan began to study the clinical efficacy of 5-fluorouracil (5-Fu) dry syrup, and in 1976, 1978, bioassay was used to determine the plasma concentration of the patients and dogs after oral administration of dry syrup, but did not explain Pharmacokinetic parameters. In this paper, fluoride ion-selective electrode method and determined by thin-layer chromatography rabbits oral dry syrup plasma concentration, and calculated pharmacokinetic parameters are as follows: K_e = 0.3108 hours -1, K_a = 0.8332 hours ~ (-1); t (1 (?) 2) (absorption) = 0.83 hours, t