红霉素为广谱抗菌素,红霉素A为其主要成分,并常含有红霉素B、C及一些差向异构体降解产物.本文采用具有高灵敏UV检测器的反相HPLC法测定固体制剂中的红霉素A,克服了过去报道的HPLC法因色谱峰拖尾、分辨率低需提高柱温,基线飘移而无法定量等缺点.该法能排除红霉素中干扰物,获得了 Erythromycin is a broad-spectrum antibiotic, erythromycin A is the main component, and often contains erythromycin B, C and some epimers degradation products.In this paper, with a highly sensitive UV detector reverse phase HPLC method Erythromycin A in solid preparation overcomes the shortcomings of the previously reported HPLC method such as tailing of chromatographic peaks, low resolution, increasing column temperature and drift of baseline without quantification, etc. The method can eliminate the interference of erythromycin and obtain It’s