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目的探讨指状青霉（Penicilliumdigitatum）提取物对大鼠肺及肝原代细胞的DNA损伤作用。方法用指状青霉提取物诱发大鼠肺及肝原代细胞的程序外DNA合成（UDS）。结果指状青霉提取物均可诱发大鼠肺及肝原代细胞的UDS，尤其是对肺原代细胞的作用更为明显（P＜0.01）。结论指状青霉提取物对大鼠肺及肝原代细胞DNA有损伤作用，从而证实其对哺乳动物细胞具有明显的遗传毒性。
Objective To investigate the DNA damage of Penicillium digitatum extract on lung and primary hepatocytes in rats. Methods Extra-procedural DNA synthesis (UDS) of rat lung and primary hepatocytes was induced using Penicillium dichotoma extract. Results The results showed that the extract of Penicillium expansum could induce the UDS of lung and primary hepatocytes, especially the primary lung cells (P <0.01). Conclusion The Penicillium expansum extracts can damage the DNA of lung and primary hepatocytes of rats, which is proved to be obviously genotoxic to mammalian cells.