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目的与方法本实验观察了小鼠感染旋毛虫后不同时期不同脏器组织中的XOD、MDA和GSH改变。结果小鼠在感染旋毛虫后的第3d至7d，其肠组织中的MDA和肝组织中MDA、XOD升高（P＜0.01），GSH降低（P＜0.01）。14d后肠中的GSH恢复，MDA降后于30d再升。肝中的XOD亦恢复，而MDA和GSH继续上升并维持较高的水平。心肌中XOD在14d时含量上升，至30d达峰值（P＜0.01）。MDA14d时也升高（P＜0.01），30d后稍回降。GSH在30d时数值才明显增高（P＜0.05）。脑中MDA与GSH呈反相改变，14d时MDA先升后降，GSH则30d后明显升高（P＜0.01）。血液中的MDA在感染后一直维持较高的水平。结论旋毛虫可诱发氧自由基对宿主脏器组织产生氧化损伤，同时引发的氧化代谢产物在组织中大量的蓄积并致宿主毒血症。两者与旋毛虫病的发生、发展有着重要的关系，并可能造成对宿主的致命性损害。
Objectives and Methods In this experiment, the changes of XOD, MDA and GSH in different organs of mice infected with Trichinella were observed. Results The MDA and XOD in intestinal tissue and the GSH decreased (P <0.01) on the 3rd and 7th day after infection with Trichinella in mice. After 14d, the GSH in the hindgut recovered and the MDA dropped again after 30d. XOD also recovered in the liver, while MDA and GSH continued to rise and maintain a high level. The content of XOD in myocardium increased on the 14th day and reached the peak value on the 30th day (P <0.01). MDA14d also increased (P <0.01), after 30d a little back down. GSH at 30d was significantly higher (P <0.05). In the brain, MDA and GSH changed in reverse phase, MDA increased first and then decreased on the 14th day, and GSH increased significantly on the 30th day (P <0.01). MDA in the blood has been maintained at a high level after infection. Conclusion Trichinella spiralis can induce oxidative damage of oxygen free radicals on the tissues of the host organism, and at the same time lead to a large amount of oxidative metabolites accumulated in the tissues and lead to host septicemia. Both have an important relationship with the occurrence and development of trichinosis and may cause fatal damage to the host.