诺米芬辛(Nomifensine)马来酸氢盐是非三环结构的第二代抗抑郁药,特点是起效快、毒副作用小。结构中四氢异喹啉4位碳原子为不对称碳原子,因此具有D(+)-和L(-)-对映体。本文以D,L-外消旋体为对照药,对D-和L-异构体进行精神药理作用强度比较。受试动物为NMRI 雄性小鼠和Wistar 雄性大鼠,经腹腔注射对映体的盐酸盐或经口服给予对映体的马来酸氢盐。将药物悬浮在1%的甲基纤维素溶液中,注射量按动物体重小鼠10 ml/kg,大鼠1 ml/kg。药理试验方法有对抗丁苯那嗪引起的小鼠眼脸下垂,对抗利血平 Nomifensine Maleate is a non-tricyclic second-generation antidepressant characterized by rapid onset and low toxic side effects. Tetrahydroisoquinoline structure of the four carbon atoms are asymmetric carbon atoms, it has D (+) - and L (-) - enantiomer. In this paper, D, L-racemate as a reference drug, D- and L-isomers of psychopharmacological Intensity comparison. The test animals were NMRI male mice and Wistar male rats, and the enantiomer hydrochloride was intraperitoneally administered or the enantiomer was hydrogenated. The drug was suspended in 1% methyl cellulose solution, the injection volume of animals by animal weight 10 ml / kg, rat 1 ml / kg. Pharmacological test methods against tetrabenazine-induced mouse eye face sagging, anti-reserpine