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目的:探究尼莫地平联合丁基苯酞对外伤性蛛网膜下腔出血患者脑微循环的影响。方法:选取我院外伤性蛛网膜下腔出血患者36例,随机分为实验组和对照组,每组18例。对照组给予尼莫地平治疗,实验组给予尼莫地平联合丁基苯酞治疗。观察并比较两组患者治疗前后脑微循环的变化情况。结果:实验组总有效率(88.9%)高于对照组(61.1%),差异有统计学意义(P<0.05);与治疗前相比,两组脑血容量(CBV)、脑血流量(CBF)水平均增高,平均通过时间(MTT)水平降低(P<0.05);与对照组相比,实验组CBV和CBF水平较高,MTT较低(P<0.05);与对照组相比,实验组格拉斯哥昏迷评分(GOS)评分较高、临床并发症发生率较低、6个月病死率较低,差异有统计学意义(P<0.05)。结论:尼莫地平联合丁基苯酞可有效改善外伤性蛛网膜下腔出血患者的脑微循环,提高患者的生存率。
Objective: To investigate the effect of nimodipine combined with butylphthalide on cerebral microcirculation in patients with traumatic subarachnoid hemorrhage. Methods: Thirty-six patients with traumatic subarachnoid hemorrhage in our hospital were randomly divided into experimental group and control group, with 18 cases in each group. The control group was treated with nimodipine, and the experimental group was given nimodipine combined with butylphthalide. The changes of cerebral microcirculation before and after treatment in both groups were observed and compared. Results: The total effective rate (88.9%) in the experimental group was higher than that in the control group (61.1%), the difference was statistically significant (P <0.05). Compared with the pretreatment group, the CBV and cerebral blood flow (P <0.05). Compared with the control group, the levels of CBV and CBF in the experimental group were higher and the MTT was lower (P <0.05). Compared with the control group, the levels of CBF and CBF in the experimental group were significantly higher than those in the control group The Glasgow Coma Scale (GOS) score in the experimental group was higher, the incidence of clinical complications was lower, and the mortality rate at 6 months was lower, with a significant difference (P <0.05). Conclusion: Combination of nimodipine and butylphthalide can effectively improve cerebral microcirculation and improve the survival rate of patients with traumatic subarachnoid hemorrhage.