豚鼠是用于研究抗坏血酸对药物代谢影响的常用动物模型,但静脉给药及连续采血较困难。最近我们用豚鼠在抗坏血酸对咖啡因药代动力学影响的研究中采用如下方法,取得了较满意的效果。静脉给药法:用毛巾裹住豚鼠进行固定,只露后腿,剪掉后腿中部的毛发,露出表浅静脉,酒精消毒后以手指压住静脉的向 Guinea pigs are common animal models used to study the effects of ascorbic acid on drug metabolism, but intravenous administration and continuous blood sampling are more difficult. Recently we used guinea pigs in ascorbic acid caffeine pharmacokinetics study using the following method, and achieved satisfactory results. Intravenous administration: with a towel wrapped around the guinea pigs fixed, only exposing the hind legs, cut the hair in the middle of the hind legs, exposing the superficial veins, after alcohol disinfection with fingers to suppress the vein to