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喘通的盐酸盐极易溶解。服用后血药浓度迅速上升,因此作用时间短,副作用强。制成双羟萘酸喘通毒性大为减小,LD_(50)为盐酸喘通的12倍,并改变了它在水中与肠液中的溶解度与溶出速度。然而双羟萘酸喘通在胃酸的 pH 影响下迅速置换成盐酸盐,仍达不到长效制剂的目的,因此必须制成肠溶口服制剂。用体外溶出试验比较了肠溶颗粒与肠溶颗
Pantothenic hydrochloride dissolves easily. After taking the blood drug concentration increased rapidly, so the role of time is short, strong side effects. Made pamoic acid asthma toxicity greatly reduced, LD_ (50) is 12 times the hydrochloric acid asthma, and changed its solubility in water and intestinal fluid and dissolution rate. However, pamoic acid is rapidly replaced with hydrochloric acid under the influence of the pH of gastric acid, which still can not achieve the purpose of long-acting preparation. Therefore, enteric oral preparations must be prepared. In vitro dissolution test compared enteric granules and enteric coated granules