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本工作给吗啡成瘾大鼠侧室注射5－HT1、5－HT2、及5－HT3受体激动剂1－（3－chlorphenyl）piperazine（简写m-cpp），α－CH3－5－HT，2－CH3－5－HT以及5－HT1受体拮抗剂Methiothepinmesylate和5-HT2受体桔抗剂Retanserine，观察对吗啡戒断反应的影响。实验结果表明，激动5－HT1受体和5－HT2受体可加重纳洛酮诱发的躯体戒断反应，阻断5－HT1受体或5－HT2受体则减轻躯体戒断反应。二种拮抗剂中以5－HT2受体拮抗剂的作用较为明显。5－HT3受体的激动剂对吗啡戒断反应无明显影响。
In this study, 5-HT1,5-HT2 and 5-HT3 receptor agonist 1- (3-chlorphenyl) piperazine (abbreviation m-cpp) -CH3-5-HT as well as Methiothepinmesylate, a 5-HT1 receptor antagonist, and Retanserine, a 5-HT2 receptor antagonist, were observed for morphine withdrawal response. The experimental results show that agonist 5-HT1 receptor and 5-HT2 receptor can aggravate naloxone-induced somatic withdrawal response, while blockade of 5-HT1 receptor or 5-HT2 receptor attenuates somatic withdrawal response. The role of 5-HT2 receptor antagonist in the two antagonists is more obvious. The 5-HT3 receptor agonist had no significant effect on morphine withdrawal response.