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本实验用配对比较设计,将选出的32对健康大白鼠,随机分为电针组和对照组。以SPG荧光组织化学方法显示儿茶酚胺,观察“足三里”穴区中去甲肾上腺素(NA)在电针镇痛和抗失血性休克过程中的变化,并探讨其在上述针刺效应中的可能作用。1.电针双侧“足三里”30min后,在电针组痛阈明显提高的同时,穴区NA荧光物质的含量明显低于对照组(P<0.01)。2.在截肢造成失血性休克时,两组动物均大量释放穴区中的NA(P=0.001);不仅动脉管壁中的NA大幅度减少,而且还涉及毛细血管和静脉。3.电针组动物死亡时间延长(P<0.05)、不死亡率提高,穴区中最后残留的NA亦远低于对照组(P<0.05)。上述结果表明,电针穴区NA的改变,可能是电针镇痛和抗失血性休克作用中的重要物质基础之一。
In this experiment, a paired comparison design was used. The 32 healthy rats selected were randomly divided into an electroacupuncture group and a control group. The catecholamines were visualized by SPG fluorescence histochemistry. The changes of norepinephrine (NA) in electroacupuncture analgesia and anti-hemorrhagic shock were observed in “Zusanli” acupoints, and the possibility of the above acupuncture effect was explored. effect. 1.After 30 minutes of electro-acupuncture on both sides of “Zusanli”, the pain threshold of the electro-acupuncture group was significantly increased. At the same time, the content of NA fluorescent substance in the cavernous area was significantly lower than that in the control group (P <0.01). 2. When amputation caused hemorrhagic shock, both groups of animals released a large amount of NA in the cavernous area (P=0.001); not only the NA in the arterial wall was greatly reduced, but also capillaries and veins were involved. 3. The time of death of the electroacupuncture group was prolonged (P<0.05), no mortality was increased, and the last remaining NA in the cavernous area was significantly lower than that in the control group (P<0.05). The above results indicate that the change of NA in electroacupuncture points may be one of the important material bases for electroacupuncture analgesia and anti-hemorrhagic shock.