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[目的]观察补阳还五汤治疗卡培他滨化疗后手足综合征疗效。[方法]使用随机平行对照方法,将52例住院患者按病志号抽签方法简单随机分两组方法随机分为两组。对照组27例维生素B6,300mg/次,1次/d。治疗组25例补阳还五汤内服和外洗:黄芪30g,当归尾20g,地龙、赤芍各15g,川芎、桃仁各10g,红花6g,甘草5g;纳差、乏力加茯苓、鸡内金各12g,白术10g;血虚加鸡血藤20g;1剂/d,水煎000m L,早晚口服。补阳还五汤煎液泡洗双手双足,30min/次。连续治疗21d为1疗程。观测临床症状、手足皮肤状况、不良反应。连续治疗8疗程,判定疗效。[结果]治疗组0级9例,Ⅰ级2例,Ⅱ级12例,Ⅲ级2例,发生率64.00%。对照组0级13例,Ⅰ级10例,Ⅱ级3例,Ⅲ级1例,发生率51.80%。[结论]补阳还五汤治疗卡培他滨化疗后手足综合征,疗效满意,无严重不良反应,值得推广。
[Objective] To observe the curative effect of Buyang Huanwu Decoction in treating hand-foot syndrome after capecitabine chemotherapy. [Methods] Using randomized parallel control method, 52 inpatients were randomly divided into two groups according to the random number of patients with different symptoms. Control group, 27 cases of vitamin B6, 300mg / time, 1 / d. The treatment group 25 cases of Buyang Huanwu Decoction and external wash: Astragalus 30g, Angelica tail 20g, earthworm, red peony 15g, Chuanxiong, peach 10g, saffron 6g, licorice 5g; anorexia, fatigue plus Poria, chicken Within the gold of 12g, Atractylodes 10g; blood deficiency plus Millettia 20g; 1 / d, decoction 000m L, morning and evening oral. Warming Yang Buwu decoction two hands wash both feet, 30min / times. Continuous treatment of 21d for a course of treatment. Observation of clinical symptoms, hand, foot and skin conditions, adverse reactions. Continuous treatment of 8 courses to determine the efficacy. [Result] There were 9 cases in grade 0, 2 in grade Ⅰ, 12 in grade Ⅱ and 2 in grade Ⅲ, the incidence rate was 64.00%. There were 13 cases of grade 0 in control group, 10 cases of grade Ⅰ, 3 cases of grade Ⅱ and 1 case of grade Ⅲ, the incidence rate was 51.80%. [Conclusion] Buyang Huanwu Decoction in the treatment of hand-foot syndrome after capecitabine chemotherapy has satisfactory curative effect and no serious adverse reactions and is worth popularizing.