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目的研究ＩＬ－２－ＰＥ４０对免疫活性Ｔ细胞的影响。方法采用ＣｏｎＡ刺激的淋巴细胞增殖试验、混合淋巴细胞培养（ＭＬＣ）及细胞毒试验。结果ＩＬ－２－ＰＥ４０对ＣｏｎＡ诱导的小鼠脾细胞有十分强的细胞毒性，能选择性地抑制ＭＬＣ中抗原活化的Ｔ细胞活性，保留未活化Ｔ细胞对ＣｏｎＡ诱导的丝裂原反应，在培养ｄ３加入ＩＬ－２－ＰＥ４０比培养开始时加入对ＭＬＣ抑制作用强。结论ＩＬ－２－ＰＥ４０能够高度选择性抑制免疫活性Ｔ细胞，是ＩＬ－２Ｒ靶向治疗中具有潜力的一种免疫抑制剂。
Objective To study the effect of IL-2-PE40 on immune-reactive T cells. Methods ConA stimulated lymphocyte proliferation test, mixed lymphocyte culture (MLC) and cytotoxicity test. Results IL-2-PE40 had a very strong cytotoxicity on ConA-induced mouse splenocytes, selectively inhibiting antigen-activated T cell activity in MLC, and retaining the activation of ConA-induced mitogen in non-activated T cells. Addition of d3 to IL-2-PE40 was stronger than that of MLC when cultured. Conclusion IL-2-PE40 can highly selectively inhibit the immune-reactive T cells and is an immunosuppressive agent with potential in the targeted therapy of IL-2R.