肾素(renin)是一种天冬氨酸蛋白酶,通过限速反应裂解血管紧张素原以产生血管紧张素I。组织局部肾素浓度显著高于循环中的浓度,提示在局部组织可能存在能与肾素结合的高亲和力受体。2002年,Nguyen等[1]首先在人类肾小球系膜细胞克隆出肾素/肾素原受体(prorenin receptor,PRR)。肾素原受体能够通过与肾素/肾素原相 Renin is an aspartic protease that cleaves angiotensinogen to produce angiotensin I by a rate-limiting reaction. Tissue local renin concentration was significantly higher than circulating concentrations, suggesting that local tissues may exist with renin binding high affinity receptors. In 2002, Nguyen et al [1] first cloned renin / PRR in human glomerular mesangial cells. Proinsulin receptors are capable of interacting with the renin / renin phase