论文部分内容阅读
目的:研究双黄连口服液对脓毒症大鼠的保护作用及其初步机制。方法:通过大鼠灌胃给药3 d后,采用盲肠结扎穿刺手术复制脓毒症大鼠动物模型。术后12 h观察大鼠死亡率,取回肠进行病理组织学观察,取血检测肝、肾功能及血常规指标,取血清测定白介素-6(IL-6)、肿瘤坏死因子(TNF-α)及脂多糖(LPS)水平。结果:与模型组比较,双黄连口服液高、中剂量可降低动物死亡率,改善肝肾功能指标,减轻回肠病理学损伤,降低血清中IL-1β、IL-6、LPS的含量。结论:双黄连口服液对脓毒症大鼠有良好的保护作用,抑制脓毒症初期炎症反应可能是其对脓毒症大鼠保护作用的药理学基础之一。
Objective: To study the protective effect and its primary mechanism of Shuanghuanglian Oral Liquid in septic rats. Methods: After 3 days of intragastric administration in rats, the animal model of sepsis was replicated by cecal ligation and puncture. After 12 h of operation, the mortality of rats was observed. The pathological changes of the intestine were observed and the liver and kidney function and blood indexes were determined by blood test. The levels of interleukin-6 (IL-6), tumor necrosis factor (TNF-α) ) And lipopolysaccharide (LPS) levels. Results: Compared with the model group, Shuanghuanglian Oral Solution can reduce the mortality of animals, improve the indexes of liver and kidney function, alleviate the damage of ileum pathology and decrease the content of IL-1β, IL-6 and LPS in serum. Conclusion: Shuanghuanglian Oral Liquid has a good protective effect on septic rats and inhibition of the inflammatory reaction at the initial stage of sepsis may be one of the pharmacological bases of its protective effect on septic rats.