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目的 评价磁共振灌注成像在术前评估脑胶质瘤组织病理学分级中的价值。方法 经手术及病理证实的胶质瘤共 2 6例。行常规MR及MR灌注成像检查。构建脑血流容积 (CBV)图和脑血流量 (CBF)图 ,计算最大相对CBV(rCBV)和最大相对CBF(rCBF) ,并与组织病理学分级对照。结果 低级组 (Ⅰ～Ⅱ级 )胶质瘤rCBV、rCBF范围分别为 0 .72～ 4.2 6和 0 .82～ 2 .89,均值分别为 2 .10± 1.18和 1.5 2± 0 .65。高级组 (Ⅲ～Ⅳ级 )胶质瘤rCBV、rCBF范围分别为 0 .89～ 10 .0 2和 1.5 0～ 6.40 ,均值分别为 5 .2 3± 1.86和 4.81± 2 .60。 2组rCBV和rCBF差别有显著性 (t检验 ,Ρ <0 .0 1)。非参数相关性分析表明rCBV与rCBF间有显著的正相关性 (r =0 .712 ,Ρ <0 .0 1)。结论 脑磁共振灌注成像对胶质瘤的术前分级有重要临床意义。
Objective To evaluate the value of MR perfusion imaging in the histopathological evaluation of gliomas before surgery. Methods Twenty-six gliomas were confirmed by operation and pathology. Routine MR and MR perfusion imaging. Cerebral blood flow volume (CBV) maps and cerebral blood flow (CBF) maps were constructed and the maximum relative CBV (rCBV) and maximum relative CBF (rCBF) were calculated and compared to histopathological grading. Results The range of rCBV and rCBF in grade Ⅰ ~ Ⅱ gliomas was 0.72 ~ 4.2 6 and 0.82 ~ 2.89 respectively, with mean values of 2.10 ± 1.18 and 1.5 2 ± 0.65, respectively. The rCBV and rCBF of gliomas in high-grade group (grade Ⅲ-Ⅳ) ranged from 0.89 to 10.02 and 1.5 to 6.40 respectively, with mean values of 5.223 ± 1.86 and 4.81 ± 2.60, respectively. The differences between rCBV and rCBF in the two groups were significant (t test, P <0.01). Non-parametric correlation analysis showed a significant positive correlation between rCBV and rCBF (r = 0.72, P <0.01). Conclusion Cerebral magnetic resonance perfusion imaging has important clinical significance for the preoperative grading of glioma.