为评估乳腺癌 (BC )患者及其家族成员 (FM )血清免疫抑制酸性蛋白 (IAP )水平的变化 ,应用单向免疫琼脂扩散法检测 2 0例乳腺癌患者和 2 0例家族成员血清IAP水平。结果发现 2 0例BC患者血清IAP水平与正常健康人 (NS )比较有显著差异 (P <0 0 1) ,FM组与NS组比较也有统计学差异 (P <0 0 1)。表明IAP与BC发生可能相关 ,IAP的检测可被用于BC易患个体的筛选。 To assess the changes of serum immuno-suppressive acid protein (IAP) levels in patients with breast cancer (BC) and their family members (FM), serum IAP levels in 20 breast cancer patients and 20 family members were measured by one-way immunodiffusion agar diffusion method. . The results showed that the serum IAP levels in 20 patients with BC were significantly different from those in healthy individuals (P < 0.01), and there was a statistical difference between the FM group and the NS group (P <0 01). It is suggested that IAP may be associated with BC, and the detection of IAP may be used for the screening of individuals susceptible to BC.