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目的初步研究中国艾滋病患者高效抗逆转录病毒治疗(HAART)过程中发生的症状性高乳酸血症的临床特征及相关影响因素。方法对北京地坛医院2005年1月至2007年12月,所有接受HAART的患者每1-2月进行临床随访,共发现8例症状性高乳酸血症患者,对其治疗前后的免疫状况、治疗方案、高乳酸血症的临床表现、实验室检测结果,以及临床处理和预后进行综合分析。结果所有8例症状性高乳酸血症患者,均在发病前服用过含有司他夫定的HAART方案9-24个月,临床症状以自觉疲乏、恶心、腹部胀痛、肌肉酸痛、运动后呼吸困难为多见,血乳酸水平3.4-10.0mmol/L。5例未出现乳酸酸中毒的症状性高乳酸血症患者,经换药或停药并对症处理后均好转;3例发展为乳酸酸中毒,病情严重,其中1例死亡。结论引起高乳酸血症的原因较多,司他夫定可能是主要因素。
Objective To study the clinical features and related factors of symptomatic hyperlipidemia occurring in Chinese AIDS patients with active antiretroviral therapy (HAART). Methods From January 2005 to December 2007, all patients who received HAART in Beijing Ditan Hospital were followed up every 1 to 2 months. Eight patients with symptomatic hyperlipoidemia were found, their immune status before and after treatment, Program, the clinical manifestations of lactic acidosis, laboratory test results, and a comprehensive analysis of clinical management and prognosis. Results All 8 patients with symptomatic hyperlipoidemia were treated with stavudine-containing HAART for 9-24 months prior to onset. Their clinical symptoms were fatigue, nausea, abdominal pain, muscle soreness and post-exercise respiration Difficult for more common, blood lactate levels 3.4-10.0mmol / L. 5 cases of lactic acidosis in patients with symptomatic hyperlipidemia, after dressing or withdrawal and symptomatic treatment were improved; 3 cases developed lactic acidosis, a serious condition, of which 1 died. Conclusions The causes of hyperlactic acidosis are more than that of stavudine may be the main factor.