目的 :探讨紫杉醇联合化疗方案对恶性肿瘤的临床疗效。方法 :以紫杉醇为主的联合方案治疗51例恶性肿瘤。结果 :完全缓解 4例 ,部分缓解 13例 ,有效率 33.3% ( 17/ 51) ;小细胞肺癌有效率37 5% ,乳腺癌有效率 4 4 %。毒副反应主要为消化道反应、骨髓抑制、脱发及轻度关节肌肉疼痛。结论 :紫杉醇联合化疗对恶性肿瘤有较好疗效。 Objective: To investigate the clinical effect of paclitaxel combined with chemotherapy on malignant tumor. Methods: A total of 51 malignant tumors were treated with paclitaxel-based regimen. Results: Four cases were completely relieved and 13 cases partially relieved. The effective rate was 33.3% (17/51). The effective rate of small cell lung cancer was 37.5% and that of breast cancer was 44%. Toxic side effects mainly gastrointestinal reactions, bone marrow suppression, hair loss and mild joint muscle pain. Conclusion: Paclitaxel combined with chemotherapy has a good effect on malignant tumors.