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目的探讨神经精神狼疮(NPLE)患者数字式脑电图变化及临床意义。方法采用数字式脑电图检测了系统性红斑狼疮(SLE)患者50例(其中NPLE 19例,非NPLE 31例),同时检测正常对照组21例数字式脑电图变化数据。结果NPLE组数字式脑电图数据明显不同于正常对照组和非NPLE组(P<0.01)。数字式脑电图改变与CSF压力、蛋白、细胞数呈正相关(P<0.05)。结论SLE患者数字式脑电图的检测对临床诊断及预测NPLE提供了帮助。数字式脑电图的改变在一定程度上反映了SLE患者神经系统损害的程度,其动态监测可作为NPLE疗效和预后的参考指标。
Objective To investigate the changes of digital EEG in patients with neuropathic lupus nephritis (NPLE) and its clinical significance. Methods Fifty patients with systemic lupus erythematosus (SLE) were enrolled in this study. Among them, 19 cases were NPLE and 31 cases were non-NPLE. Digital EEG data of 21 cases of normal control group were also detected. Results Digital EEG data in NPLE group were significantly different from those in normal control group and non-NPLE group (P <0.01). The changes of digital EEG were positively correlated with CSF pressure, protein and cell number (P <0.05). Conclusion Digital EEG detection in SLE patients is helpful in clinical diagnosis and prediction of NPLE. The change of digital EEG partly reflects the degree of nervous system damage in patients with SLE, and its dynamic monitoring can be used as a reference index of curative effect and prognosis of NPLE.