本文研究了硝基安定对健康受试者静注、口服、直肠给药的药物动力学和生物利用度,并比较房室分析与无模型限制两种方法计算的药物动力学结果。实验对象为7名男性健康志愿受试者,23～27岁,平均体重72±6kg,肝、肾功能正常。给药前禁食24小时,给药后3小时内禁食、水、烟,试验期间保持仰卧。给药方式和剂量:静注含5.24mg 硝基安定的丙二醇-乙 In this paper, the pharmacokinetics and bioavailability of nitrazepam for intravenous, oral and rectal administration in healthy subjects were studied. Pharmacokinetic results were calculated by comparing atrioventricular analysis and model-free restriction. The subjects were seven healthy male volunteers, 23 to 27 years old, the average body weight of 72 ± 6kg, liver and kidney function was normal. Fasting for 24 hours before administration, fasting, water, and smoke within 3 hours after administration, and keeping supine during the test. Mode of administration and dose: intravenous injection of 5.24mg of nitroprussone - B