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目的:川芎嗪注射液对大鼠急性期脑出血GFAP的影响及应用时机的探讨。方法:采用大鼠尾状核胶原酶注射法造模,分假手术组、模型组、6h、12h、24h、36h治疗组,观察出血区脑组织病理形态改变,检测血肿体积和胶质纤维酸性蛋白(GFAP)含量的变化。结果:与模型组相比,6h治疗组可见出血坏死灶扩大,GFAP更高表达(P>0.05);而12h、24h、36h治疗组病灶较小,GFAP表达降低(P<0.05),尤以12h治疗组降低最为明显(P<0.01)。结论:川芎嗪注射液在一定时间窗(12h或以后)对急性期脑出血大鼠可减轻脑水肿,使血肿变小,其作用可能是通过降低GFAP表达来实现的。
Objective: To investigate the effect of tetramethylpyrazine injection on acute cerebral hemorrhage (GFAP) in rats and the application of time. METHODS: Rat caudate nucleus collagenase injection was used to establish a model, divided into sham operation group, model group, 6h, 12h, 24h, and 36h treatment groups. The pathological changes of brain tissue in the hemorrhage region were observed, and the hematoma volume and glial fiber acidity were measured. Changes in protein (GFAP) content. RESULTS: Compared with the model group, hemorrhagic necrosis increased and GFAP expression was higher in the 6h treatment group (P>0.05), while lesions in the treatment group were smaller at 12h, 24h, and 36h, and GFAP expression was decreased (P<0.05). The decrease was most obvious in the 12h treatment group (P<0.01). CONCLUSION: Ligustrazine injection can relieve cerebral edema and make hematoma smaller in rats with acute intracerebral hemorrhage during a certain time window (12h or later). The effect may be achieved by reducing the expression of GFAP.