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目的 :探讨贲门癌高、低发区贲门上皮各级病变组织C erbB2蛋白表达的变化特征。方法 :采用组织病理学和免疫组织化学ABC法 ,分析高发区正常贲门上皮 (NOR) 10例 ,慢性浅表性贲门炎 (CSG)组织 2 3例 ,慢性萎缩性贲门炎 (CAG)组织 16例 ,贲门上皮不典型增生 (DYS) 14例 ,贲门癌 (GCA) 70例和低发区NOR 32例 ,CSG组织 38例 ,CAG组织 15例 ,DYS 18例 ,GCA组织 39例中C erbB2蛋白表达情况。结果 :贲门癌高发区从CSG→CAG→DYS→GCA ,C erbB2蛋白阳性表达率分别为 17%、38%、86 %和 81% ;GCA组织中低分化组C erbB2蛋白阳性率 (5 7% )低于高、中度分化组 (92 % ) (P <0 .0 5 )。低发区从CSG→CAG→DYS→GCA ,C erbB2蛋白阳性率分别为 2 1%、2 0 %、5 6 %和 5 1% ;GCA组织中低分化组C erbB2蛋白阳性率 (80 % )高于高、中度分化组 (33% ) (P <0 .0 5 )。结论 :贲门上皮极轻度病变已发生不同程度的C erbB2表达变化 ,并随病变进展而呈现不同程度的升高趋势 ;高发区贲门上皮各级病变的升高趋势 ,特别是DYS ,明显高于低发区居民 ;C erbB2是贲门上皮癌变 ,特别是早期病变的重要分子变化
OBJECTIVE: To investigate the changes of C erbB2 protein expression in cardiac lesions of cardia carcinoma at high and low incidence areas. Methods: Histopathological and immunohistochemical ABC methods were used to analyze the distribution of normal cardia epithelium (NOR) in 10 high-incidence areas, 23 cases of chronic superficial cardialitis (CSG) and 16 cases of chronic atrophic carditis (CAG) , Cardiac dysplasia (DYS) in 14 cases, cardia cancer (GCA) in 70 cases and low incidence of NOR in 32 cases, CSG in 38 cases, CAG in 15 cases, DYS in 18 cases and GCA in 39 cases, and C erbB2 protein expression Happening. Results: The positive rates of CSG → CAG → DYS → GCA and C erbB2 protein expression in GCA were 17%, 38%, 86% and 81% respectively. The positive rates of C erbB2 protein in GCA tissues were lower than those in GCA tissues (57% ) Was lower than that in the high and moderately differentiated groups (92%) (P <0.05). The positive rates of CSB → CAG → DYS → GCA and C erbB2 in low-risk area were 21%, 20%, 56% and 51% respectively. The positive rate of C erbB2 protein in poorly differentiated GCA tissues was 80% Higher than the high and moderately differentiated group (33%) (P <0.05). CONCLUSION: C erbB2 expression changes in cardia epithelial very mild lesions with varying degrees of progression, and with the progression of the lesions showed a rising trend to varying degrees; the incidence of cardia epithelial lesions in all the high incidence areas, especially DYS, was significantly higher than Low incidence of residents; C erbB2 is cardia cancer, especially in early lesions of important molecular changes