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文章简介MicroRNA(miRNA)是一类小分子非编码RNA,广泛存在于真核生物中,通过调控其靶mRNA的翻译而影响多种细胞生命活动。核RNA酶Ⅲ的Drosha蛋白剪切miRNA初级转录本是miRNA经典生物合成步骤的关键环节。越来越多的证据表明miRNA的生物合成过程可以被多种因素调节,然而,人们并不清楚Drosha自身是怎样被调控的。本研究发现,应激可以影响Drosha的生物学功能c正常情况下,Drosha与DGCR8(DiGeorge syndrome critical
MicroRNA (miRNA) is a kind of small molecule non-coding RNA, which is widely existed in eukaryotes and affects many kinds of cell life activities by regulating the translation of its target mRNA. Drosha Protein Cleavage of Nuclear RNase III Primary miRNA transcripts are key steps in the classical miRNA biosynthetic steps. There is growing evidence that miRNA biosynthesis can be regulated by many factors, however, it is unclear how Drosha itself is regulated. This study found that stress can affect the biological function of Drosha c Under normal circumstances, Drosha and DGCR8 (DiGeorge syndrome critical