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选择诊断明确的未分化脊柱关节病患者７０例，分成正清风痛宁治疗组与雷公藤多甙对照组，观察其总体疗效及对休息痛、压痛、肿胀、关节功能的影响，并分析其安全耐受性。同时观察血清中ｒＧ、ＩｇＧ、ＩＬ－１、ＴＮＦ－ａ水平变化。结果治疗组与对照组的总体疗效相似，医生评价与患者评价总有效率均达８０％以上。治疗组对休息痛、关节压痛改善优于对照组，Ｐ＜０．０５。对关节肿胀、关节功能改善及血清中ＩｇＧ、ＩＬ－１、ＴＮＦ－ａ水平降低２组相似。表明正清风痛宁对未分化脊柱关节病患者能有效地缓解休息痛、关节压痛、肿胀与改善关节功能，安全性较高。其治疗作用机理与降低体内ＩＬ－１、ＴＮＦ－ａ水平，从而调节机体免疫因子网络有关。
70 patients with undifferentiated spondyloarthropathy diagnosed clearly were divided into the Zhengqingfengtongning group and the Tripterygium wilfordii control group, and their overall efficacy and effects on rest pain, tenderness, swelling and joint function were observed, and their safety was analyzed. Tolerance. At the same time, serum levels of rG, IgG, IL-1 and TNF-a were observed. Results The overall efficacy of the treatment group was similar to that of the control group. The total effective rate of the doctor’s evaluation and the patient’s evaluation was over 80%. The treatment group had better improvement on rest pain and joint tenderness than the control group, P<0.05. Joint swelling, improvement of joint function, and reduction of serum IgG, IL-1, and TNF-a levels were similar in the 2 groups. It shows that Zhengqingfengtongning can effectively relieve rest pain, joint tenderness, swelling and improve joint function in patients with undifferentiated spondyloarthropathy, and has higher safety. Its therapeutic mechanism is related to reducing the level of IL-1 and TNF-a in the body and regulating the body’s immune factor network.