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目的研究某驻军医院患者肺炎克雷伯菌的感染状况及耐药性,为医院感染控制及临床合理用药提供依据。方法通过细菌分离鉴定技术和药敏试验方法,对某驻军医院临床送检标本的检测结果进行分析。结果该驻军医院2013年度从患者送检标本中共分离出病原菌2 522株,其中肺炎克雷伯菌401株,占15.90%,主要分离自呼吸道标本和术后切口分泌物,其感染患者相对集中于老年病科、呼吸内科、重症监护病房及心血管内科。临床分离的肺炎克雷伯菌对氨苄西林、头孢唑啉、复方新诺明的耐药率较高,对喹诺酮类抗菌药物耐药率低于30%,对亚胺培南敏感。结论该医院肺炎克雷伯菌分离率较高,以呼吸道和手术感染切口为主,对临床常用抗菌药物产生不同程度的耐药。
Objective To study the infection status and drug resistance of Klebsiella pneumoniae in a military hospital and provide basis for the control of nosocomial infection and clinical rational drug use. Methods Bacterial isolation and identification techniques and drug susceptibility test methods were used to analyze the detection results of clinical specimens from a garrison hospital. Results A total of 22 522 pathogens were isolated from the patient specimens in 2013, of which 401 were Klebsiella pneumoniae (15.90%), mainly from respiratory specimens and postoperative incision secretions. The infected patients were relatively concentrated in Geriatrics, Respiratory Medicine, Intensive Care Unit and Cardiovascular Medicine. Clinically isolated Klebsiella pneumoniae ampicillin, cefazolin, cotrimoxazole higher resistance rate of quinolone antibacterial drug resistance rate of less than 30% sensitive to imipenem. Conclusions The Klebsiella pneumoniae isolated from this hospital has a high separation rate, mainly respiratory and surgical incision, which produces different levels of resistance to antibiotics commonly used in clinical practice.