用ChE组织化学结合图像分析技术,探讨了可乐定对梭曼中毒动态过程的影响。结果可乐定对梭曼抑制ChE的最大抑制程度没有作用,而显著地降低了ChE抑制速率。脑组织的皮质和延脑区域ChE动态抑制过程受可乐定影响明显,而底节影响较轻,说明梭曼中毒的毒性表现主要由脑皮质和延脑ChE抑制所致。 ChE histochemistry with image analysis technology to explore the clonidine on the Soman’s dynamic process. Results Clonidine had no effect on the maximal inhibitory effect of soman on ChE, but significantly reduced the ChE inhibitory rate. The dynamic inhibition of ChE in cortical and extensional brain regions was significantly affected by clonidine and less in the basal ganglia, indicating that the toxicity of soman intoxication was mainly caused by the inhibition of cerebral cortex and extensorium ChE.