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为探讨ｐ５３基因缺失在非小细胞肺癌（ＮＳＣＬＣ）发病机制中的作用，应用Ｓｏｕｔｈｅｒｎ印迹杂交技术检测１７例ＮＳＣＬＣｐ５３基因缺失情况，发现７例（４１．２％）存在ｐ５３基因缺失，发生淋巴结扩散的ＮＳＣＬＣ，其ｐ５３基因缺失率较高。结果提示ｐ５３基因的缺失与ＮＳＣＬＣ的发生、发展相关。
To explore the role of deletion of p53 gene in the pathogenesis of non-small cell lung cancer (NSCLC), 17 cases of NSCLC p53 gene deletion were detected by Southern blot hybridization. 7 cases (41.2%) had p53 gene deletion and lymph node proliferation. NSCLC has a high deletion rate of p53 gene. The results suggest that the deletion of p53 gene is related to the occurrence and development of NSCLC.