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间充质干细胞(MSCs)是一种具有自我更新和多向分化潜能的成体干细胞,存在于骨髓、脂肪组织、脐血及多种胎儿组织。它可分泌多种细胞因子及生长因子,促进造血干细胞(HSC)的增殖与分化。MSCs还具有免疫调节、抗炎和组织修复作用,可减轻移植物抗宿主病(GVHD)及其他移植相关并发症。
Mesenchymal stem cells (MSCs) are adult stem cells that have the potential for self-renewal and multidirectional differentiation in bone marrow, adipose tissue, cord blood and various fetal tissues. It can secrete a variety of cytokines and growth factors, and promote the proliferation and differentiation of hematopoietic stem cells (HSC). MSCs also have immunomodulatory, anti-inflammatory and tissue repair effects that reduce graft-versus-host disease (GVHD) and other transplant-related complications.