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目的：探讨淋巴丝虫感染中Ｔ淋巴细胞的免疫应答机制。方法：检测安徽省班氏丝虫病流行区人群及感染马来丝虫的长爪沙鼠体外诱生的白细胞介素２（ＩＬ－２）和γ干扰素（ＩＦＮ－γ）。结果：对非特异性有丝分裂原ＰＨＡ及ＣｏｎＡ的刺激，各组人群外周血单核细胞（ＰＢＭＣ）产生ＩＬ－２及ＩＦＮ－γ水平无显著差异。对马来丝虫成虫抗原的刺激，微丝蚴血症者ＰＢＭＣ产生ＩＬ－２及ＩＦＮ－γ水平比流行区无症状、无微丝蚴血症者显著低下，长爪沙鼠实验结果与人群的相似。结论：本实验提示，班氏丝虫病流行区微丝蚴血症者及马来丝虫微丝蚴血症长爪沙鼠的Ｔ细胞对丝虫抗原处于一种低应答状态，且这种受抑制的Ｔ细胞主要是Ｔｈ１亚群细胞。
Objective: To investigate the immune response mechanism of T lymphocytes in lymphatic filariasis infection. Methods: Interleukin 2 (IL-2) and interferon-γ (IFN-γ) induced in vitro were detected in the population of Bancrofoo filariasis endemic areas in Anhui province and in the male Mongolian gerbils infected with malayian filariasis. Results: There was no significant difference in the level of IL-2 and IFN-γ produced by peripheral blood mononuclear cells (PBMCs) in all groups stimulated by nonspecific mitogen PHA and ConA. On the Malay worm adult antigen stimulation, microfilariaemia PBMC produce IL-2 and IFN-γ levels than the prevalence of asymptomatic, no microfilariaemia were significantly lower, Meriones unguiculatus experimental results and population Similar. CONCLUSIONS: The present study suggests that T-cells of microfilariae and Microfilaria microfilariae in gerbil follicular filariasis endemic areas are in a low response to filarial antigens, and that this The T cells that are repressed are mainly Th1 subpopulation cells.