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水杨酸类药物(S)是医疗上常用药之一,国外文献屡见报道该药引起急、慢性中毒以及发生类似Reye氏综合征(RD)的情况。1880年Starko等学者认为S可为RD的原发病因之一。但也有学者持不同见解,而考虑临床上所发生的一系列症状是与S本身的药物代谢动力学,以及病人机体的生理、生化、病生、免疫机制的改变有关。同时也涉及到研究时与原始设计和分析方面有某些片面性,如选择病例的偏性、资料收集的偏性等本文拟作一简述。
Salicylates (S) is one of the commonly used medications in medicine. It is often reported in foreign literature that the drug causes acute and chronic poisoning and the occurrence of Reye’s syndrome (RD). In 1880, scholars such as Starko considered S as one of the primary causes of RD. However, some scholars hold different opinions and consider a series of clinical symptoms that are related to the pharmacokinetics of S itself and the changes of the physiological, biochemical, disease-causing and immune mechanisms of the patient’s body. At the same time, it also involves some unilateral aspects of research and original design and analysis, such as the bias of selected cases and the bias of data collection.