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目的建立广州地区健康儿童抗双链DNA抗体的参考区间,为筛查及诊断儿童自身免疫性疾病提供参考。方法 2012-2013年调查广州地区学校统一体检或门诊健康体检的适龄儿童(2~18岁),通过调查表和实验室检测结果严格筛选出学龄前、学龄期及中学期三组健康儿童(每组120例,男女比例1∶1),确立抗双链DNA抗体的参考区间。抗双链DNA抗体用酶联免疫吸附法(ELISA)测定,所有数据采用SPSS19.0进行统计分析,偏态分布数据采用中位数及百分位数[M(P_(25)~P_(75))]表示,参考区间双侧取P2.5~P97.5、单侧上限取P99。结果广州地区健康儿童抗双链DNA抗体的参考区间为(0.89~72.08)IU/ml,99%可信区间下的正常参考区间单侧上限P99为81 IU/ml。不同年龄、不同性别间比较,差异无统计学意义(P>0.05)。结论儿童抗双链DNA抗体的正常参考区间较推荐的成人参考区间偏低。因此建立儿童的抗双链DNA抗体的正常参考区间具有临床意义。
Objective To establish a reference interval for anti-double-stranded DNA antibody in healthy children in Guangzhou, and to provide a reference for screening and diagnosis of autoimmune diseases in children. Methods A total of 2 to 18-year-old healthy children aged 2 to 18 years from January to September of 2013 in Guangzhou were enrolled in this study. The health status of preschool children, school age children and secondary school children were detected by questionnaires and laboratory tests. Group of 120 cases, male to female ratio of 1: 1), establish anti-double-stranded DNA antibody reference interval. The anti-double-stranded DNA antibody was determined by enzyme-linked immunosorbent assay (ELISA). All data were analyzed by SPSS19.0. The skewed distribution data were calculated using median and percentile [M (P 25- P 75 ))] Said that both sides of the reference interval to take P2.5 ~ P97.5, unilateral upper limit to P99. Results The reference interval of anti-double-stranded DNA antibody of healthy children in Guangzhou was (0.89-72.08) IU / ml. The unilateral upper limit P99 of the normal reference interval under the 99% confidence interval was 81 IU / ml. There was no significant difference between different age and gender (P> 0.05). Conclusion The normal reference interval for anti-double-stranded DNA antibody in children is lower than the recommended reference interval for adults. Therefore, the establishment of children with anti-double-stranded DNA antibodies of the normal reference interval of clinical significance.