论文部分内容阅读
目的对临床ICU分离的常见致病菌及对抗生素耐药性进行了分析,为临床合理使用抗生素提供借鉴。方法收集2015年6月至2016年6月本院ICU收治的420例患者分离的420份细菌标本,运用纸片扩散法检测常用抗菌药的致病菌及其耐药性。结果 ICU常见的致病菌有革兰氏阴性菌、革兰氏阳性菌、真菌;革兰氏阴性菌主要有鲍曼不动杆菌、铜绿假单胞菌、大肠埃希菌等,革兰氏阳性菌主要有金黄色葡萄球菌、屎肠球菌、凝固酶阴性球菌。革兰氏阳性菌对万古霉素外的多种抗生素均有较高的耐药性,而革兰氏阴性菌中除肺炎克雷伯菌、大肠埃希菌对亚胺培南不耐药外,其他致病菌对临床常用的抗生素均有不同程度的耐药性。结论 ICU病房以革兰氏阴性菌为主,各种致病菌对临床常用的抗生素均有耐药性,应明确患者的致病菌类型,选择耐药性低的抗生素,以减轻患者痛苦和经济负担。
Objective To analyze the common pathogenic bacteria isolated from clinical ICU and the antibiotic resistance, and provide reference for the rational use of antibiotics in clinic. Methods 420 bacterial samples collected from 420 patients in ICU of our hospital from June 2015 to June 2016 were collected. The pathogenic bacteria and drug resistance of commonly used antibiotics were detected by disk diffusion method. Results The common pathogens in ICU were Gram-negative bacteria, Gram-positive bacteria and fungi. Gram-negative bacteria mainly included Acinetobacter baumannii, Pseudomonas aeruginosa, Escherichia coli, Positive bacteria are Staphylococcus aureus, Enterococcus faecium, coagulase-negative cocci. Gram-positive bacteria on vancomycin outside a variety of antibiotics have higher resistance, and gram-negative bacteria in addition to Klebsiella pneumoniae, Escherichia coli imipenem non-resistance outside , Other pathogens commonly used in clinical antibiotics have different levels of resistance. Conclusion ICU wards are mainly Gram-negative bacteria, all kinds of pathogens are commonly used in clinical antibiotics are resistant, should be clear pathogenic bacteria in patients, select low antibiotic resistance to reduce patient pain and economic burden.