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目的比较血清胆碱酯酶(CHE)/γ-谷氨酰转肽酶(GGT)比值在肝硬化患者中的变化。方法选取医院收治的肝硬化患者100例,并选取同期进行健康体检者79例为对照组,对2组均进行CHE和GGT检测,观察血清CHE/GGT比值。结果肝硬化患者血清CHE/GGT比值明显低于对照组(P<0.05);肝功能B级和C级患者血清CHE/GGT比值均低于肝功能A级患者,且肝功能C级患者血清CHE/GGT比值低于肝功能B级患者(P<0.05)。结论肝硬化患者血清CHE/GGT比值降低,且随着肝脏损害程度的加重而逐渐下降,能反映肝硬化患者的病情变化。
Objective To compare the changes of serum cholinesterase (CHE) / γ-glutamyl transpeptidase (GGT) in cirrhotic patients. Methods 100 patients with cirrhosis admitted in hospital were enrolled and 79 healthy subjects were selected as the control group during the same period. CHE and GGT were detected in both groups, and the serum CHE / GGT ratio was observed. Results The serum CHE / GGT ratio in cirrhotic patients was significantly lower than that in the control group (P <0.05). The serum CHE / GGT ratios in patients with grade B and C liver function were lower than those in patients with grade A liver function, / GGT ratio was lower than in patients with grade B liver function (P <0.05). Conclusion The serum CHE / GGT ratio decreased in patients with cirrhosis, and gradually decreased with the degree of liver damage, reflecting the changes of patients with cirrhosis.