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氧林肯霉素(Clindamycin)治疗中度和严重的痤疮可代替四环素。尤其是一些痤疮杆菌对四环素耐药的患者。作者应用氯林肯霉素和四环素分别治疗70例(男21,女49;年龄14～51岁)和72例(男20,女52;年龄14～51岁)痤疮患者。口服氯林肯霉素3～8个月,150毫克,日二次。口服四环素3～38个月,250毫克,日二次.治疗前后血常规和肝功能(血清胆红素、谷丙转氨酶)均正常。服四环素者无腹泻。而应用氯林肯霉素的患者有9例发生腹泻,每天2～9次(平均4次),大便软。停服氯林肯霉素之后2～4周停止腹泻。未见其他不适或发生伪膜性结肠炎者。
Clindamycin treats moderate and severe acne instead of tetracycline. In particular, some patients with tetracycline resistance to acne bacteria. The authors used clindamycin and tetracycline to treat 70 (male 21, female 49; age 14-51) and 72 (male 20, female 52; age 14-51) acne patients, respectively. Oral clindamycin 3 to 8 months, 150 mg, two times a day. Oral tetracycline 3 to 38 months, 250 mg, twice a day before and after treatment of blood and liver function (serum bilirubin, alanine aminotransferase) were normal. Tetracycline without diarrhea. Nine patients with clindamycin had diarrhea 2 to 9 times per day (mean, 4) and soft stools. Stop taking clindamycin 2 to 4 weeks after stopping diarrhea. No other discomfort or pseudomembranous colitis occurred.