论文部分内容阅读
脱氢延胡索碱(dehydrocorydaline)系从延胡索(Corydalis turtschaninovii f yanhu-suo Y.H.Chow et C.C.Hsü)块茎中提得的一种季铵碱。药理实验证明具有扩张冠状动脉,明显提高小鼠在常压和减压下对缺氧的耐受能力,具有一定的中枢镇静和抗士的宁的惊厥作用,能增加小鼠心肌对 Rb~(86)的摄取率,增加小鼠心肌营养性血流量,并对垂体后叶所引起的小鼠急性心肌缺血具有一定的保护作用。作为治疗冠心病药物的延胡索全碱制剂——可达灵,通过451病例的临床观察,证明有较好的疗效,已于1979年12月召开了鉴定会。其主
Dehydrocorydaline is a quaternary ammonium base obtained from the tubers of Corydalis turts chaninvivi f yanhu-suo Y.H.Chow et C.C.Hsü. Pharmacological experiments have shown that the expansion of the coronary arteries, significantly improve the ability of mice to withstand hypoxia under normal pressure and reduced pressure, have a certain central sedation and anticonvulsant effect of antipsychotics, can increase the mouse myocardial Rb ~ ( The uptake rate of 86) increased the myocardial nutrient blood flow in mice and had a protective effect on acute myocardial ischemia in mice induced by the posterior pituitary. As a drug for the treatment of coronary heart disease, Corydophorae, a total alkaloid preparation of Telisol, has been proved to have better curative effect through the clinical observation of 451 cases. The appraisal meeting was held in December 1979. Its owner