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本文研究了临床剂量消炎痛对人基础和精氨酸刺激血浆生长激素水平的作用。 7例正常受试者,随机应用消炎痛25mg,每日4次或安慰剂,连续3日。第4日晨禁食。静息30分钟,取静脉血样。测定血清胰岛素、血浆葡萄糖、生长激素、胰高血糖素和游离脂肪酸水平。静滴盐酸精氨酸20g,30分钟以上。在10、20和30分钟取血样,中止静滴,在45和60分钟再次取血样,至少一周后,交替应用消炎痛或安慰剂3日。按上述方法再次静
This article studies the effect of a clinical dose of indomethacin on human basal and arginine-stimulated plasma levels of growth hormone. Seven normal subjects were randomized to receive either indomethacin 25 mg 4 times a day or placebo for 3 consecutive days. 4th morning fasting. Rest for 30 minutes, take venous blood samples. Serum insulin, plasma glucose, growth hormone, glucagon, and free fatty acid levels were measured. Intravenous hydrochloride arginine 20g, 30 minutes or more. Blood samples were withdrawn at 10, 20, and 30 minutes, stopped intravenously, and blood samples were taken again at 45 and 60 minutes. Indomethacin or placebo was alternately administered for at least one week for 3 days. Static again according to the above method