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目的分析2014-2015年泉州市人乳头瘤病毒(HPV)检测试点项目结果,以了解农村地区HPV感染情况以及宫颈癌筛查情况。方法通过妇幼重大公共卫生信息系统导出泉州市2014-2015年HPV检测试点项目所有个案,所有数据导入SPSS13.0统计学软件进行分析。结果泉州市HPV检测试点项目2014年HPV感染率为3.48%,2015年为4.04%,两年感染率排名前5的亚型均为52、58、18、16、68型;项目共筛查出4例宫颈癌患者,疾病检出率为8/万;筛查出CIN 1及以上疾病(含宫颈癌)63例,疾病检出率为1.26%。晋江市与南安市、石狮市在HPV阳性人数分布、感染HPV型别分布及细胞学检查结果上的分布比较,差异均无统计学意义(均P>0.05);晋江市与石狮市阴道镜及病理检查结果比较,差异无统计学意义(均P>0.05),而晋江市与南安市阴道镜及病理检查结果分布比较,差异有统计学意义(χ~2=10.501,P=0.005);HPV阳性、阴性人群年龄的双侧T检验结果比较,差异有统计学意义(t=-2.779,P=0.006);HPV阳性人群中出现了两个年龄峰值,第一峰值为37~38岁,第二峰值为46岁。结论初筛机构是影响宫颈癌筛查质量的因素之一;应提高HPV检测试点项目数据利用率,对相关结果作进一步研究;加强相关经济学研究,完善项目方案。
Objective To analyze the results of the pilot project of human papillomavirus (HPV) in Quanzhou from 2014 to 2015 so as to understand the HPV infection in rural areas and the screening of cervical cancer. Methods All cases of HPV testing pilot project in Quanzhou from 2014 to 2015 were deduced from major public health information system of women and children. All the data were imported into SPSS13.0 statistical software for analysis. Results The prevalence of HPV infection in Quanzhou was 3.48% in 2014 and 4.04% in 2015, and the top 5 subtypes in two years of infection were all types 52, 58, 18, 16 and 68. The project screened out 4 cases of cervical cancer patients, the disease detection rate was 8 / million; Screening CIN 1 and above diseases (including cervical cancer) in 63 cases, the disease detection rate was 1.26%. There was no significant difference in the distribution of HPV positive number, HPV type distribution and cytology results between Jinjiang City, Nanan City and Shishi City (all P> 0.05). There was no significant difference between Jinjiang City and Nanan City and Shishi City There was no significant difference between the two groups (P> 0.05), while the results of colposcopy and pathological examination in Jinjiang and Nanan were statistically different (χ ~ 2 = 10.501, P = 0.005) There was significant difference between the two groups (P = 0.006). There were two age peaks in the HPV positive population, the first peak was 37-38 years old, The second peak is 46 years old. Conclusion The screening agency is one of the factors influencing the screening quality of cervical cancer. The data utilization rate of HPV testing project should be increased, and the related results should be further studied. The relevant economics should be strengthened to improve the project plan.