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目的探讨诱骗受体3(DcR3)在食管鳞癌中的表达、临床病理意义及与肿瘤浸润T细胞(TIL)的关系。方法采用免疫组化SABC法检测60例食管鳞癌中DcR3的表达情况及TIL的分布、数量,分析DcR3与各临床病理因素及与TIL的关系。结果 DcR3在食管鳞癌组织的表达率高于正常组织(P<0.05)。DcR3表达与食管鳞癌的分化程度和浸润深度相关(P<0.05),而与年龄、性别、肿瘤大小和有无淋巴结转移无相关性(P>0.05)。DcR3表达阳性肿瘤组织中的TIL数少于表达阴性肿瘤者(P<0.05)。结论 DcR3在食管鳞癌中的异常表达,可能通过阻断细胞凋亡和逃避免疫监视等作用促进肿瘤发生发展,检测DcR3表达有助于判断食管鳞癌的恶性程度。
Objective To investigate the expression of decoy receptor 3 (DcR3) in esophageal squamous cell carcinoma, its clinicopathological significance and its relationship with tumor infiltrating T cells (TIL). Methods Immunohistochemical SABC method was used to detect the expression of DcR3 and the distribution and quantity of TIL in 60 esophageal squamous cell carcinomas. The relationship between DcR3, clinicopathological factors and TIL were analyzed. Results DcR3 expression in esophageal squamous cell carcinoma was higher than that in normal tissue (P <0.05). The expression of DcR3 was correlated with the degree of differentiation and depth of invasion in esophageal squamous cell carcinoma (P <0.05), but not with age, sex, tumor size and lymph node metastasis (P> 0.05). The number of TILs in DcR3-positive tumors was less than that in those with negative tumors (P <0.05). Conclusions Abnormal expression of DcR3 in esophageal squamous cell carcinoma may promote the tumorigenesis through blocking apoptosis and avoiding immune surveillance. Detecting DcR3 expression may be helpful to judge the malignancy of esophageal squamous cell carcinoma.