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Le~x糖脂是一组带有x决定簇[Gal B_1-4Fu(1-3 Glc NAc)]的糖脂,一系列的研究提示为胚胎抗原。已知变癌时,细胞表面正常的糖脂标记减少或消失,出现新的肿瘤相关糖脂标记。据报道,国外已从人消化系统腺癌组织中提取出一系列具有Le~x血型活性的糖脂组织抗原用于癌肿的诊断,并获得单克隆抗体。本文参考Hakomori等介绍的方法,从人胃腺癌组织中分离得到具有Le~x血型活性的糖脂抗原-6B神经节苷脂,现报告如下。
Le ~ x glycolipids are a group of glycolipids with the x determinant [Gal B_1-4Fu (1-3 GlcNAc)]. A series of studies have suggested that embryonic antigens are present. Known cancer, the cell surface normal glycolipid markers reduce or disappear, the emergence of new tumor-associated glycolipid markers. It has been reported that a series of glycolipid tissue antigens with Le ~ x blood group activity have been extracted from human digestive system adenocarcinoma abroad for the diagnosis of cancer and monoclonal antibodies have been obtained. Reference to Hakomori and other methods introduced in this paper, isolated from human gastric adenocarcinoma with Le ~ x blood type activity of glycolipid antigen-6B ganglioside, are reported as follows.