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目的:探讨非甾体类药(NSAIDs)致急性胃粘膜病变的临床表现及内镜特点。方法:回顾性分析54例NSAIDs导致急性胃粘膜病变患者的临床资料。结果:服用NSAIDs后临床表现为上腹痛,返酸、嗳气者32例(593%)、呕血8例(14.8%)、黑便25例(46.3%)、呕血伴血便10例(18.5%)。内镜下表现为弥漫性胃粘膜充血、水肿及多发性糜烂49例(90.7%),伴应激性浅表溃疡23例(42.6%)。结论:NSAIDs是急性胃粘膜病变的重要病因,对于需长期服用NSAIDs的高危患者,既往有溃疡病史,年龄>60岁,同时服用两种以上NSAIDs或与糖皮质激素同服者应给予预防性治疗。
Objective: To investigate the clinical manifestations and endoscopic features of acute gastric mucosal lesions induced by non-steroidal drugs (NSAIDs). Methods: The clinical data of 54 patients with acute gastric mucosal lesions caused by NSAIDs were retrospectively analyzed. Results: After taking NSAIDs, 32 cases (59.3%) had nausea, acid reflux, 8 cases (14.8%) with vomiting, 25 cases (46.3%) with melena and 10 cases (18.5%) with hematemesis and bloody stool. Endoscopic showed diffuse gastric mucosal congestion, edema and multiple erosions in 49 cases (90.7%), with stress superficial ulcer in 23 cases (42.6%). CONCLUSIONS: NSAIDs are an important cause of acute gastric mucosal lesions. For high-risk patients requiring chronic long-term NSAIDs, there is a history of ulcers in patients with a history of> 60 years of age and two or more NSAIDs or prophylactic treatment with glucocorticoid .