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对亚胺培南与其它6种头孢菌素对888株临床致病菌的抗菌谱及耐药率进行了比较。对于大部分需氧菌和脆弱拟杆菌,亚胺培南显示了强大的抗菌活性,特别对于部分对其它6种头孢菌素耐药的菌株也具有很好的抗菌活性。2mg/L以下的亚胺培南可以抑制90％菌株的生长。对于大肠杆菌、克雷伯肺炎杆菌、痢疾志贺氏菌、沙门氏菌属、奇异变形杆菌、产气肠杆菌,亚胺培南与头孢噻肟、头孢他定、头孢曲松的抗菌活性相似;对于阴沟肠杆菌、枸機酸杆菌属、沙雷氏菌属、不动杆菌属、金葡菌、表皮葡萄球菌、化脓性链球菌、肺炎链球菌、粪链球菌及脆弱拟杆菌,亚胺培南的抗菌活性强于其它6种抗生素。根据美国临床实验室标准全国委员会(NCCLS)推荐的标准进行耐药性调查的结果显示,本实验中细菌对亚胺培南的耐药率最低。
The antibacterial spectrum and drug resistance rate of 888 clinical pathogenic bacteria between imipenem and 6 other cephalosporins were compared. For most aerobic and Bacteroides fragilis, imipenem showed strong antibacterial activity, especially for some strains resistant to the other 6 cephalosporins also have good antibacterial activity. Imipenem below 2 mg / L inhibited the growth of 90% of the strains. Klebsiella pneumoniae, Shigella dysenteriae, Salmonella, Proteus mirabilis, Enterobacter aerogenes, imipenem and cefotaxime, ceftazidime, ceftriaxone antibacterial activity similar to; for Enterobacter cloacae, Citrobacter, Serratia, Acinetobacter, Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pyogenes, Streptococcus pneumoniae, Streptococcus faecalis and Bacteroides fragilis, imipenem The antibacterial activity than the other six kinds of antibiotics. According to the results of the drug resistance survey recommended by the National Committee for Clinical Laboratory Standards (NCCLS), the resistance rate of the bacteria to imipenem was the lowest in this experiment.