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作者用体内外模型对新的7-二甲基吡啶取代的喹诺酮类化合物 WIN57273 进行了抗菌活性的评价。用琼脂和肉汤稀释法进行的体外实验表明它对革兰氏阳性菌和阴性菌具有广谱活性,对葡萄球菌抗菌活性最强。对凝固酶阳性葡葡球菌的 MIC_(90)≤0.002μg/ml;对凝固酶阴性葡萄球菌 MIC_(90)为0.008μg/ml;对肠球菌的 MIC_(90)为0.06μg/ml。对链球菌 A 族和 B 族以及肺炎球菌的抗菌活性与前相当。总的来说,它对革兰氏阴性菌的 MIC_(90)≤1μg/ml(除了粘质沙雷氏菌 MIC_(90)为16μg/ml,弗氏柠檬酸细菌 MIC_(90)为4μg/
The authors evaluated the antimicrobial activity of a novel quinolone-substituted quinolone compound WIN57273 using in vitro and in vivo models. In vitro experiments with agar and broth dilution method showed that it has a broad spectrum of activity against Gram-positive and -negative bacteria, the strongest antibacterial activity against Staphylococcus. MIC_ (90) ≤0.002μg / ml for coagulase positive Staphylococcus aureus; 0.008μg / ml for Coagulase negative Staphylococcus MIC_ (90); and 0.06μg / ml for Enterococcus. Streptococcus A and B groups and pneumococcal antibacterial activity as before. In summary, it has a MIC of (90) ≦ 1 μg / ml against Gram-negative bacteria (16 μg / ml except Serratia marcescens MIC 90 and 4 μg /