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目的评价胃肠起搏器治疗GERD的有效性。方法将60例病人分为两组,胃肠起搏治疗组30例,莫沙比利治疗组30例,两组对照分析。治疗前后检查胃电图,记录胃电平均频率、平均幅值、胃电节律紊乱百分比、正常慢波百分比、餐后/餐前功率比,观察临床症状。结果胃肠起搏器治疗组、莫沙比利组治疗前后临床症状均改善,两组的治疗前后症状积分比较差别有显著性(P<0.05)。两组治疗后餐前、餐后平均频率较治疗前明显改善(P<0.05),趋向正常频率;餐前、餐后波形平均幅值无明显变化(P>0.05);餐前/餐后功率比均大于1,组间差别无显著性(P>0.05);胃电节律紊乱百分比改善明显,组间差别有显著性(P<0.05);正常慢波百分比改善,组间差别无显著性(P>0.05)。结论胃肠起搏器治疗GERD可改善临床症状及胃电生理的频率。
Objective To evaluate the effectiveness of gastrointestinal pacemaker in the treatment of GERD. Methods Sixty patients were divided into two groups: 30 patients in the gastrointestinal pacing group and 30 patients in the mosapride group. The control group was compared between the two groups. Before and after treatment, check the electrogastrogram, record the average gastric electrical frequency, the average amplitude, gastric electrical rhythm disorders percentage, the percentage of normal slow wave, postprandial power ratio, observe the clinical symptoms. Results The clinical symptoms of gastrointestinal pacemaker treated group and mosapride group were improved before and after treatment. There were significant differences in symptom scores between the two groups before and after treatment (P <0.05). The average pre-meal and post-meal frequency of both groups improved significantly (P <0.05) and normal frequency (P <0.05). The average amplitude of pre-meal and post-meal waveforms had no significant change (P> 0.05) (P> 0.05); the percentage of gastric electrical rhythm disorder improved significantly (P <0.05); the percentage of normal slow wave improved, but the difference between groups was not significant (P> 0.05) P> 0.05). Conclusion Gastrointestinal pacemaker treatment of GERD can improve the clinical symptoms and gastric electrophysiology frequency.