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在寻找天然血管紧张素Ⅱ受体拮抗剂的过程中,发现吴茱萸(Evodia rutaecarpa)甲醇提取物对~3H标记的血管紧张素Ⅱ与雄性SD大鼠肝膜受体的结合显示强的抑制作用(在100μg/ml浓度时,抑制率为80％)。为此,以体外血管紧张素Ⅱ结合试验为指导,从吴茱萸丁醇提取物中分离到3种喹诺酮生物碱吴茱萸新碱(1)、1-甲基-2-[(4Z,7Z)-4,7-十三碳二烯)-4(1H)-喹诺酮(2)、1-甲基-2-[(6Z,9Z)-6,9-十五碳二烯]-4(1H)-
In the search for natural angiotensin II receptor antagonists, it was found that the methanol extract of Evodia rutaecarpa showed a strong inhibitory effect on the binding of ~3H-labeled angiotensin II to male SD rat liver membrane receptors ( At a concentration of 100 μg/ml, the inhibition rate was 80%). To this end, three quinolone alkaloids, evodiamine (1), 1-methyl-2-[(4Z, 7Z)-4, were isolated from the butanol extract of Evodia rutaecarpa under the guidance of in vitro angiotensin II binding assay. ,7-Tridecadiene)-4(1H)-quinolone (2), 1-methyl-2-[(6Z,9Z)-6,9-pentadecadiene]-4(1H)-