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目的评价血管紧张素转换酶抑制剂(ACEI)治疗老年退行性心脏瓣膜病合并慢性心力衰竭及心律失常的临床疗效。方法收集2000年6月至2007年9月云南南涧县中医院收治的90例老年退行性心脏瓣膜病合并慢性心力衰竭及心律失常患者,随机分为对照组和治疗组。对照组常规治疗,如吸氧、利尿剂、洋地黄、血管扩张剂和对症支持治疗;治疗组在常规治疗基础上,根据患者耐受情况给予 ACEI 类药物,3个月为一个疗程。疗程结束后比较两组治疗后受损瓣膜以及心功能和心律失常的改善情况。结果两组治疗后心功能及心律失常有明显改善(P<0.05),治疗组与对照组比较差异有显著性意义(P<0.01)。结论 ACEI 类药物治疗老年退性行心脏瓣膜病合并慢性心力衰竭及心律失常疗效明显,安全可靠。
Objective To evaluate the clinical efficacy of angiotensin converting enzyme inhibitor (ACEI) in the treatment of senile degenerative heart valvular disease complicated with chronic heart failure and arrhythmia. Methods Ninety elderly patients with senile degenerative valvular heart disease and arrhythmia admitted to Nanjian County Chinese Medicine Hospital of Yunnan Province from June 2000 to September 2007 were randomly divided into control group and treatment group. Control group conventional treatment, such as oxygen, diuretics, digitalis, vasodilators and symptomatic and supportive treatment; the treatment group on the basis of routine treatment, according to patient tolerance given ACEI drugs, 3 months for a course of treatment. At the end of the course of treatment, the valvular impaired valve and the improvement of cardiac function and arrhythmia were compared between the two groups after treatment. Results After treatment, cardiac function and arrhythmia were significantly improved in both groups (P <0.05). There was significant difference between the treatment group and the control group (P <0.01). Conclusion ACEI drugs for elderly patients with valvular heart disease with chronic heart failure and arrhythmia efficacy is obvious, safe and reliable.