小DNA病毒B19,是1975年在人血中被首次发现的,直至最近,才认识它是一种病原。虽然过去许多调查表明,很多人已与该病毒发生过广泛的接触,但未发现它同任何一种特定的疾病有联系;1981年,才知道它同镰状细胞贫血患者的各种再生障碍性危象有关。这危象起因于红细胞生成完全停止,使原先患有贫血的病人发生短暂但极其严重的贫血。研究者发现,红细胞生成的停止,系该小DNA病毒感染并破坏了骨髓中未成熟的红细胞所致。去年又证明,小DNA The small DNA virus B19, first discovered in human blood in 1975, was not recognized until recently as a causative agent. Although many surveys in the past have shown that many people have had extensive contacts with the virus, they have not been found to be associated with any particular disease; it was only known in 1981 that it was associated with various aplastic disorders in patients with sickle-cell anemia Crisis related. The crisis was caused by the complete cessation of erythropoiesis, which resulted in a brief but extremely serious anemia in previously anemic patients. The researchers found that the cessation of erythropoiesis is caused by the infection of small DNA viruses and the destruction of immature red blood cells in the bone marrow. Last year proved that small DNA