丝虫病是我国危害人民健康最烈的五大寄生虫病之一。过去一直使用海群生治疗,对微丝蚴作用较强,对成虫效力不明显,不能作为根治药物,且副反应较大,特别是在治疗马来丝虫病患者时,往往因严重副反应而影响普治工作的开展。30多年来迄无新药问世。为了寻找对微丝蚴和成虫均有强烈作用的新药,上海医药工业研究院与中国医学科学院寄生虫病研究所协作发现硝基呋喃甲醛缩氨基衍生物类型对棉鼠丝虫阳性棉鼠体内成虫及微丝蚴均有较明 Filariasis is one of the five major parasitic diseases that endanger people’s health in our country. In the past, seaquats have been used to treat microfilariae and have no obvious effect on adults. They can not be used as curative drugs and have a large side effect. Especially in the treatment of Malayan filariasis patients, they often suffer serious side effects Affect the conduct of the Prussian surgery. Over the past 30 years until the advent of new drugs. In order to find a new drug that has a strong effect on both microfilaria and adults, Shanghai Institute of Pharmaceutical Industry collaborated with the Institute of Parasitic Diseases, Chinese Academy of Medical Sciences, to find out the effect of nitrofurylformaldehyde derivatives on cotton And microfilaria are more bright