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目的 了解乙型肝炎(乙肝)病毒(HBV)感染标志的分布情况。方法 2 0 0 3年11月在山东省济阳县开展了15～4 0岁人群HBV感染标志分布的横断面调查,共采集合格静脉血1994人份。乙肝病毒表面抗原(HBsAg)、乙肝病毒表面抗体(抗HBs)、乙肝病毒核心抗体(抗HBc)均用固相放射免疫(SPRIA)法检测。结果 15～4 0岁人群HBsAg、抗HBs、抗 HBc和HBV感染率分别为6 5. 2 %、2 4 .77%、30 . 99%和4 3 .6 3%。HBsAg流行率随年龄的增长而升高,男女性别之间HBsAg流行率的差异无显著的统计学意义。结论 该次调查正值我国将乙肝疫苗纳入儿童计划免疫之际,此调查可为之提供本底资料,并为进一步探讨乙肝疫苗扩大免疫策略提供参考
Objective To understand the distribution of hepatitis B virus (HBV) infection markers. Methods In November 2003, a cross-sectional survey of the distribution of HBV infection markers in 15 ~ 40-year-olds was conducted in Jiyang County, Shandong Province. A total of 1994 samples of qualified venous blood were collected. Hepatitis B virus surface antigen (HBsAg), hepatitis B virus surface antibody (anti-HBs), hepatitis B virus core antibody (anti HBc) were detected by solid phase radioimmunoassay (SPRIA) method. Results The infection rates of HBsAg, anti-HBs, anti-HBc and HBV among 15 ~ 40 years old were 65.2%, 24.77%, 30.99% and 43.36%, respectively. The prevalence of HBsAg increased with advancing age. There was no significant difference in the prevalence of HBsAg between men and women. Conclusions This survey coincides with the planned immunization of hepatitis B vaccine in our country. This survey can provide the background information and provide reference for further exploring the strategy of expanding immunization of hepatitis B vaccine